2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (513):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-159615
    Cbl-b-IN-21 2851878-87-8
    Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608).
    Cbl-b-IN-21
  • HY-107450
    PROTAC Her3-binding moiety 2 2103332-05-2
    PROTAC Her3-binding moiety 2 is a Her3 inhibitor. PROTAC Her3-binding moiety 2 can be used for synthesis of PROTAC Her3 Degrader-8 (HY-153796).
    PROTAC Her3-binding moiety 2
  • HY-181897
    mHTT ligand-1 1903786-86-6
    mHTT ligand-1 is an mHTT ligand. As a Ligand for Target Protein for PROTAC, mHTT ligand-1 can be used to develop and design PROTAC-based mHTT degraders, such as PROTAC mHTT Degrader-1 (HY-181879). mHTT ligand-1 is applicable to research related to Huntington's disease.
    mHTT ligand-1
  • HY-171442A
    (R)-PIN1 ligand-2
    (R)-PIN1 ligand-2 is a PIN1 ligand, and can be used for synthesis of PROTACs, such as P1D-34 (HY-171334A).
    (R)-PIN1 ligand-2
  • HY-173373
    AR ligand-39 2156591-18-1
    AR ligand-39, an androgen receptor (AR) ligand, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). AR ligand-39 can be used for synthesis PROTAC AR Degrader-10 (HY-173372).
    AR ligand-39
  • HY-168314
    BTK ligand 11
    BTK ligand 11 is a PROTAC target protein ligand that can be used to synthesize BCPyr (HY-142621).
    BTK ligand 11
  • HY-186219
    PIN1 ligand-3
    PIN1 ligand-3 (Compound I-1) is a PIN1 ligand. PIN1 ligand-3 serves as a Ligand for Target Protein for PROTAC for the synthesis of PIN1 PROTAC degraders, such as PROTAC PIN1 degrader-2 (HY-186218). PIN1 ligand-3 is applicable in cancer research.
    PIN1 ligand-3
  • HY-163949
    SMARCA2/4-IN-3
    SMARCA2/4-IN-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-3 can be used for synthesis PROTAC SMARCA2/4-degrader-19 (HY-163877).
    SMARCA2/4-IN-3
  • HY-182344
    MLKL ligand-2
    MLKL ligand-2 is a mixed lineage kinase domain-like pseudokinase (MLKL) PROTAC ligand with a KD of 9.408 μM. MLKL ligand-2 forms hydrogen bond networks and hydrophobic interactions with specific MLKL residues, and stabilizes MLKL in hepatic cells. MLKL ligand-2 can be used to synthesize PROTAC MLKL Degrader-3 (HY-182343).
    MLKL ligand-2
  • HY-176796
    SHP2-IN-43 2458219-45-7
    SHP2-IN-43 (Compound 5) is a SHP2 inhibitor with an IC50 of 98.7 nM. SHP2-IN-43 can be used as a PROTAC target ligand in the synthesis of SHP2-D26 (HY-145162).
    SHP2-IN-43
  • HY-181852
    CBP/p300 ligand 10 3098454-51-1
    CBP/p300 ligand 10 (Compound 3-E) is a CBP/p300 degrader. CBP/p300 ligand 10 also serves as a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) and can be used to synthesize the PROTAC CBP/p300 Degrader-2 (HY-181261).
    CBP/p300 ligand 10
  • HY-177389
    IAP ligand 5
    IAP ligand 5 is a IAP ligand. IAP ligand 5 can be used to synthesize PROTAC ERα Degrader-2 (HY-111846).
    IAP ligand 5
  • HY-174470
    IRAK4 ligand-14 3065496-26-3
    IRAK4 ligand-14 is a ligand for IRAK4. IRAK4 ligand-14 can be used for synthesizing PROTACs such as APH02174 (HY-174455).
    IRAK4 ligand-14
  • HY-183769
    FAK-IN-31
    FAK-IN-31 is a FAK inhibitor with antiproliferative activity against a variety of cancer cell lines. FAK-IN-31 serves as a PROTAC target protein ligand for the development of FAK-targeted PROTAC degrader heads, such as PROTAC FAK degrader 5 (HY-183768). FAK-IN-31 can be used in the research of colorectal cancer, pancreatic cancer, breast cancer, hepatocellular carcinoma and lung cancer.
    FAK-IN-31
  • HY-174871
    AY-2
    AY-2 is a binding ligand for FTH1 and can be used to synthesize PROTACs such as AY-4 (HY-174867).
    AY-2
  • HY-184006
    BMX ligand-1 1863114-58-2
    BMX ligand-1 (Compound 9) is a BMX ligand. BMX ligand-1 serves as a target protein ligand for the synthesis of BMX PROTAC degraders, such as IHMT-BMX-068 (HY-184005). BMX ligand-1 is applicable to prostate cancer research.
    BMX ligand-1
  • HY-168271
    ER ligand-2
    ER ligand-2 (Ligands for Target Protein for Compound 24) is the ligand of ER. ER ligand-2 can be used for synthesis PROTAC ER Degrader-11 (HY-168270).
    ER ligand-2
  • HY-161791
    Mpro ligand 2 2816967-14-1
    Mpro ligand 2 (Compound 8) is the ligand for target protein, which can be used for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789).
    Mpro ligand 2
  • HY-186022
    YAP/TAZ-TEAD-IN-3 2714434-41-8
    YAP/TAZ-TEAD-IN-3 is a YAP/TAZ-TEAD interaction inhibitor with an IC50 of 1.8 nM. YAP/TAZ-TEAD-IN-3 can be used as a TEAD1 ligand to construct PROTACs, such as PROTAC TEAD degrader-2 (HY-186021).
    YAP/TAZ-TEAD-IN-3
  • HY-180178
    BLIMP-1 ligand-1
    BLIMP-1 ligand-1 (Compound 56) is a BLIMP-1 ligand. BLIMP-1 ligand-1 can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC BLIMP-1, such as PROTAC BLIMP-1 degrader-1 (HY-180177). BLIMP-1 ligand-1 can be used in multiple myeloma research.
    BLIMP-1 ligand-1